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EPAR Technical Report #346
Assessing Pharma’s Constraints, Opportunities, and Investment Options in Global Health R&D: An Analysis of SEC 10-K Filings
Publication Date: 04/23/2018
Type: Literature Review
Abstract

The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.

Executive Summary, Full Report
EPAR Technical Report #59
Agriculture and Climate Change
Publication Date: 12/15/2009
Type: Research Brief
Abstract

Agriculture and Climate Change: Part I

With estimated global emissions of 5,969-6,615 metric tons (Mt) of carbon dioxide (CO2) per year, agriculture accounts for about 13.5% of total global anthropogenic emissions of greenhouse gases (GHG). Deforestation contributes about 11.8% of total GHG emissions, releasing about 5,800 Mt CO2 per year. Developing countries are largely responsible for emissions from agriculture and deforestation, with the developing countries of South Asia and East Asia accounting for 17% and 25% of global agricultural emissions respectively. Sub-Saharan Africa (SSA) accounts for about 13% of global emissions from agriculture and 15% of emissions from land use change and forestry. This report examines the biophysical and economic potential of mitigating agriculture and land use GHG emissions, and provides a summary on the current and projected impact of global carbon market mechanisms on emission reductions. 

Agriculture and Climate Change: Part II

This report covers two topics related to agriculture and climate change in developing countries. The first section discusses the role of agricultural offsets in mitigating greenhouse gas emissions. Recent negotiations around a post-Kyoto Protocol agreement have included debate about whether agricultural carbon sequestration projects should be eligible under the Clean Development Mechanism (CDM). We examine the reasons for supporting or opposing this type of CDM reform and how these reasons relate to impacts on development goals and smallholder farmers, scientific uncertainty about carbon sequestration, and philosophical disagreement about the use of emission offsets. The second section covers proposed agricultural adaptation activities in Africa and other developing countries. While the majority of developing countries have outlined immediate adaptation needs in National Adaptation Programs of Action (NAPAs), few have made progress in implementing adaptation activities. We find that issues related to financial resources, scientific and technical information, and capacity building continue to challenge developing countries in preparing for the impacts of climate change.
 

Research Brief: Part I, Research Brief: Part II
EPAR Research Brief #99
Aflatoxin Prevalence in the Developing Worlds
Publication Date: 01/31/2009
Type: Literature Review
Abstract

Aflatoxin is a naturally occurring carcinogen produced by the fungus Aspergillus, particularly Aspergillus Flavus and Aspergillus Parasiticus. Aflatoxin contamination places an economic and health burden on farmers throughout the developing world, but reliable prevalence data are difficult to obtain. This report analyzes data from 25 primary research articles published within the last 15 years in order to provide a summary of aflatoxin contamination in the developing world. This report is divided into three parts, roughly aligning with phases of the agricultural value chain. Data for prevalence at the production and processing stage are presented first, followed by data for prevalence during storage, and finally by a summary of data for aflatoxin levels at consumption and point-of sale. We find maize and groundnuts to be the crops most affected by aflatoxin, while Southeast Asia and Sub-Saharan Africa are the geographic areas most likely to be affected. Agroecological conditions including warm humid climates, irrigated hot deserts, and droughts contribute to aflatoxin contamination, and we find that contamination can occur throughout the value chain. 

Literature Review, Results Coding