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The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.
Asset-Based Community Development (ABCD) is a development framework which focuses on the capacities, skills and social resources of people and their communities, rather than initially focusing on the needs, deficiencies, constraints and problems of a community.1 This document contains three sections. The first section summarizes several papers which either (1) apply ABCD or similar asset-focused development frameworks in a rural/agricultural context and to development in Sub-Saharan Africa, or (2) provide general guidance on the implementation of ABCD approaches to development. The second section provides more detail on how Oxfam and the Coady International Institute have applied ABCD in Ethiopian communities.
Finally, in order to provide an example of how ABCD might be applied to a Foundation project, the third section briefly notes how an ABCD strategy might differ from the Foundation’s proposed constraints-based Bihar strategy.
This report provides a summary of Tanzania’s agriculture sector, crop production, agricultural productivity and yield levels, risks, and policies and reforms. This review uses resources found on the University of Washington Libraries system and Google Scholar, as well as the websites of the Government of Tanzania, FAO, and World Bank. We find that Tanzanian agriculture workers comprise 80% of the population and farm a wide variety of crops, ranging from staple crops such as maize, cassava, and rice, to export crops such as coffee, cotton, tobacco, tea, and sugar. Smallholder farmers face increasing risks from climate change, pests, diseases, and land degradation, among others. While they have some resources available, such as farmer groups and limited access to ICTs, they lack important resources such as credit and inputs. We find that Tanzania’s land tenure and agriculture policies may further complicate the lives of smallholders through increased taxes and administrative processes. Through the Agricultural Sector Development Programme (ASDP) reform, however, the Government of Tanzania hopes to empower farmers and improve service delivery.