Evans School Policy Analysis & Research Group (EPAR)

The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.

As part of the Crops & Climate Change series, this brief is presented in three parts: 1) An evaluation of the importance of Sorghum and Millet in SSA, based on production, net exports, and caloric need, 2) A novel analysis of historical and projected climate conditions in Sorghum and Millet growing regions, followed by a summary of the agronomic and physiological vulnerability of Sorghum and Millet crops, 3) A summary of current resources dedicated to sorghum and millet, based on research and development investments and National Adaptation Programmes of Action. Our analysis indicates that sorghum and millets may become increasingly important in those areas of SSA predicted to become hotter and subject to more variable precipitation as a result of climate change. Although sorghum and millet are currently grown on marginal agricultural lands and consumed for subsistence by poorer population segments, climate change could render these drought- and heat-tolerant crops the most viable future cereal production option in some areas where other cereals are currently grown. Fewer international development resources are currently devoted to sorghum and millet than are devoted to other cereal grains, and current resource allocation may not reflect the increased reliance on these grains necessitated by projected climactic changes.

Water is a critical input for significantly enhancing smallholder farmer productivity in Sub-Saharan Africa (SSA) where less than 5% of farm land is irrigated, and in India where 42% of farm land is irrigated.  For many years, donors have invested in human-powered treadle pump technologies as a point of entry for smallholder farmers unable to afford motorized pumps. In spite of some successes in treadle pump promotion, however, there is a widespread perception that as soon as smallholder farmers can afford to they quickly transition to motorized diesel- powered pumps. While diesel pumps substantially ease farmers’ workload, they pollute excessively (both in terms of local air quality and greenhouse gas emissions), pump excessive amounts of water, and put farmers at the mercy of cyclical spikes in fuel prices. This brief provides an overview of state-of-the-art alternative energy pumps, including technologies available and implementation lessons learned from China, India, Africa, South America and other regions. Through a literature review, written surveys and phone interviews with water pump producers and non-governmental organizations (NGOs) we evaluate the availability, affordability, and adoption rates of alternative energy technologies in developing countries. Our findings suggest that no single alternative energy water pumping system is a “silver bullet” for rural smallholder irrigation needs. Biofuels may prove a successful short- to intermediate-term solution for farmers who already have access to diesel pumps, but other problems associated with diesel engines, including high maintenance costs and excessive water use remain even when biofuels are used. Solar systems eliminate pollution almost entirely, reduce water consumption, and eliminate the need to purchase fuels. However solar systems are typically prohibitively expensive for smallholder farmers. Wind powered pumping solutions have not proven successful to date, with high costs and irregular wind patterns (either too little or too much wind) proving substantial barriers to widespread adoption.

Agriculture in Sub-Saharan Africa is expected to experience major impacts from climate change, leaving the already food-insecure region subject to the largest contractions of agricultural incomes and food availability. As part of the Crops & Climate Change series, this brief presents an evaluation of the importance of rice in SSA, a novel analysis of historical and projected climate conditions in rice-growing regions in relation to rice's agronomic requirements, and a summary of current resources dedicated to rice. This three-pillared approach serves to identify gaps in resources dedicated to rice productivity in SSA in light of the crop’s resilience to projected changes in climate and increasing importance in the region’s food security. Overall, this analysis indicates that the importance of rice in SSA is increasing even as climate change is projected to have significant effects on the temperature in rice-growing regions. The current resources dedicated to rice research and dissemination of improved methods are insufficient to meet Africa’s rice production needs, and may not reflect the importance of the crop for the region’s food security under the future projected climate.