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EPAR Technical Report #346
Assessing Pharma’s Constraints, Opportunities, and Investment Options in Global Health R&D: An Analysis of SEC 10-K Filings
Publication Date: 04/23/2018
Type: Literature Review
Abstract

The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.

Executive Summary, Full Report
EPAR Research Brief #219
Crop Value Chains: Sweet Potatoes in Ethiopia
Publication Date: 01/27/2013
Type: Literature Review
Abstract

This report provides a genderal overview of the sweet potato value chain in Ethiopia. The first section describes trends in sweet potato production and consumption since the early 1990s. The second section describes the uses and importance of sweet potatoes in Ethiopia. The final section discuss major issues in production, post-production, and marketing. The literature available on sweet potetoes in Ethiopia was quite limited and draws on the wider literature on sweet potatoes in East Africa where needed. We find that Ethiopia ranks fifteenth in the world in terms of sweet potato production. Production has been rising quickly since 2008, following a period of slow decline in the early 2000s. Yields have also been rising slowly since 2008, but are below their peak from 2001. Sweet potato roots are consumed domestically, mostly by poor rural households. The vines also provide an important source of feed for livestock during the dry season. Major constraints to sweet potato production in Ethiopia include a lack of quality planting materials, pests and disease, and underdeveloped markets.

Full Report
EPAR Research Brief #217
Crop Value Chains: Sweet Potatoes in Uganda
Publication Date: 01/23/2013
Type: Literature Review
Abstract

Uganda is the biggest sweet potato producer in Africa in terms of area harvested and production, although Burundi, Rwanda and Madagascar have significantly higher yields.  Sweet potato is a major crop in Uganda, ranking third in cultivated area following plantains and cassava. Sweet potato ranks fourth in gross agricultural production value. The Government of Uganda has recognized sweet potatoes as an important crop for the country and a research priority, especially through establishing the National Agricultural Research Organization potato center. This report provides a general overview of the sweet potato value chain in Uganda. The first section describes trends in sweet potato production and consumption since 1996. The second section describes the varieties grown and their uses. The final section summarizes current practices and constraints in production, processing, and marketing.

Full Report