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EPAR Technical Report #346
Publication Date: 04/23/2018
Type: Literature Review
Abstract

The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.

EPAR Technical Report #345
Publication Date: 12/01/2017
Type: Literature Review
Abstract

The share of private sector funding, relative to public sector funding, for drug, vaccine, and diagnostic research & development (R&D) differs considerably across diseases. Private sector investment in overall health R&D exceeds $150 billion annually, but is largely concentrated on non-communicable chronic diseases with only an estimated $5.9 billion focused on "global health", targeting diseases that primarily affect low and middle-income countries (LMICs). We examine the evidence for five specific disincentives to private sector global health R&D investment: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed and sunk costs, and downstream rents from imperfect markets. Though all five may affect estimates of net returns from an investment decision, they are worth examining separately as each calls for a different intervention or remediation to change behavior.

EPAR Technical Report #349
Publication Date: 11/30/2017
Type: Literature Review
Abstract

Donor countries and multilateral organizations may pursue multiple goals with foreign aid, including supporting low-income country development for strategic/security purposes (national security, regional political stability) and for short-and long-term economic interests (market development and access, local and regional market stability). While the literature on the effectiveness of aid in supporting progress on different indicators of country development is inconclusive, donors are interested in evidence that aid funding is not permanent but rather contributes to a process by which recipient countries develop to a point that they are economically self-sufficient. In this report, we review the literature on measures of country self-sufficiency and descriptive evidence from illustrative case studies to explore conditions associated with transitions toward self-sufficiency in certain contexts.

  

EPAR Technical Report #338
Publication Date: 05/19/2017
Type: Literature Review
Abstract

The concept of global public goods represents a framework for organizing and financing international cooperation in global health research and development (R&D). Advances in scientific and clinical knowledge produced by biomedical R&D can be considered public goods insofar as they can be used repeatedly (non-rival consumption) and it is difficult or costly to exclude non-payers from gaining access (non-excludable). This paper considers the public good characteristics of biomedical R&D in global health and describes the theoretical and observed factors in the allocation R&D funding by public, private, and philanthropic sources.

EPAR Research Brief #219
Publication Date: 01/27/2013
Type: Literature Review
Abstract

This report provides a genderal overview of the sweet potato value chain in Ethiopia. The first section describes trends in sweet potato production and consumption since the early 1990s. The second section describes the uses and importance of sweet potatoes in Ethiopia. The final section discuss major issues in production, post-production, and marketing. The literature available on sweet potetoes in Ethiopia was quite limited and draws on the wider literature on sweet potatoes in East Africa where needed. We find that Ethiopia ranks fifteenth in the world in terms of sweet potato production. Production has been rising quickly since 2008, following a period of slow decline in the early 2000s. Yields have also been rising slowly since 2008, but are below their peak from 2001. Sweet potato roots are consumed domestically, mostly by poor rural households. The vines also provide an important source of feed for livestock during the dry season. Major constraints to sweet potato production in Ethiopia include a lack of quality planting materials, pests and disease, and underdeveloped markets.

EPAR Research Brief #217
Publication Date: 01/23/2013
Type: Literature Review
Abstract

Uganda is the biggest sweet potato producer in Africa in terms of area harvested and production, although Burundi, Rwanda and Madagascar have significantly higher yields.  Sweet potato is a major crop in Uganda, ranking third in cultivated area following plantains and cassava. Sweet potato ranks fourth in gross agricultural production value. The Government of Uganda has recognized sweet potatoes as an important crop for the country and a research priority, especially through establishing the National Agricultural Research Organization potato center. This report provides a general overview of the sweet potato value chain in Uganda. The first section describes trends in sweet potato production and consumption since 1996. The second section describes the varieties grown and their uses. The final section summarizes current practices and constraints in production, processing, and marketing.

EPAR Technical Report #211
Publication Date: 12/14/2012
Type: Literature Review
Abstract

This report provides a general overview of the sweet potato value chain in Tanzania. The first section describes trends in sweet potato production and consumption since 1990. The second section describes the uses and importance of sweet potatoes in Tanzania. The final section outlines current practices and constraints in production, post-production, and marketing. Tanzania ranks fifth in the world in quantity of sweet potatoes produced. Production and consumption of sweet potatoes have been relatively constant over the past 10 years, although both production and consumption in this period have been high in comparison to earlier decades. We find that sweet potato yields increased in the early 2000s, but have stagnated since, and are far short of potential yields. Sweet potato consumption is almost entirely domestic and plays an important role in nutrition and food security for smallholder farmers. Sweet potato production faces a variety of constraints, including pests and disease, short shelf life, lack of planting materials, damage during handling, and lack of market access.

EPAR Technical Report #223
Publication Date: 12/10/2012
Type: Literature Review
Abstract

Cassava is a tuber crop originating in South America and grown in tropical and subtropical areas throughout the world. Cassava use varies significantly by region. In Africa, cassava is primarily grown for food. In Asia, production is typically for industrial purposes, including ethanol, while in Latin America and the Caribbean it is commonly used in animal feed. Both roots and leaves are consumed, though most information on production focuses on roots. There are bitter and sweet varieties; bitter cassava has a high cyanide content and must be processed prior to consumption, while sweet varieties can be eaten directly. This report presents information about current production, constraints, and future potential of cassava. We discuss cassava’s importance in Africa, current worldwide production, projections for supply and demand, production constraints, and current policies affecting cassava production and trade. We include global information but focus on Africa, particularly Nigeria, Ghana, Uganda, and Tanzania.

EPAR Technical Report #199
Publication Date: 07/27/2012
Type: Literature Review
Abstract

Over the past 20 years, global wheat production and consumption have increased significantly. Production has increased 28%, or about 1.3% annually, and consumption has increased about 24%, or 1.1% annually. A small number of countries consistently account for over 90% of the export market, but the import market is more diversified and involves many more countries. Wheat is primarily used for food, seed, and industry; only 20% of wheat production is used for animal feed. This brief provides a global overview of the wheat value chain, but with specific attention to three focus countries: Ethiopia, India (specifically the Bihar region), and Bangladesh. While these three countries currently have a limited impact in the global wheat market, projections of wheat production and demand suggest that over the next 20 years demand in Bangladesh and Ethiopia will increasingly exceed supply, while India will become a net importer by 2030.

EPAR Technical Report #204
Publication Date: 07/27/2012
Type: Literature Review
Abstract

This report provides a general overview of the wheat market in Ethiopia. The first section describes trends in wheat production and consumption over the past twenty years and summarizes recent trade policy related to wheat. The second section presents the findings of a literature review of the wheat value chain in Ethiopia, beginning with seed research and ending with sales. The third section outlines the nutritional content of wheat as well as potential substitutes. Finally, wheat consumption in Ethiopia is discussed in more depth, including the role of wheat in Ethiopian diets, substitute grain markets, and projected consumption in 2030. We find that over the past twenty years, wheat production and consumption have both increased in Ethiopia despite the existence of strong markets for potential substitute grains. The Ethiopian government has played an active role in wheat markets, such as making large investments in extension programs and adopting protectionist policies to ensure government control of all commercial grain imports. Despite these efforts, Ethiopia is expected to face a growing supply deficit in the absence of increased domestic productivity and/or changes to government policy.