Research Topics

Dataset

EPAR Technical Report #346
Publication Date: 04/23/2018
Type: Literature Review
Abstract

The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.

EPAR Research Brief #316
Publication Date: 12/13/2015
Type: Literature Review
Abstract

The literature on poverty’s causes and cures in developing countries posits a variety of contributing factors. Most researchers acknowledge that a sustained exit from poverty is complex and no single causal pathway from poverty to non-poverty exists. In this review, we present a summary framework for categorizing the various theorized pathways out of poverty, and evaluate the empirical evidence for which interventions and resulting outcomes are most frequently and most strongly associated with poverty alleviation. We conducted a literature review on pathways out of poverty for low-income households in developing countries and identified and categorized general strategies and outcomes demonstrated to be empirically associated with poverty alleviation. We organized the general strategies into four asset groups that could be targeted to alleviate poverty: human, natural, built / financial, and social / political. Much of the literature presents positive results on poverty alleviation, but it is difficult to compare across studies because many of the studies were conducted in different countries and at different scales, and use a variety of outcome measures.

EPAR Research Brief #312
Publication Date: 07/30/2015
Type: Literature Review
Abstract

This brief reviews the evidence of realized yield gains by smallholder farmers attributable to the use of high-quality seed and/or improved seed varieties. Our analysis suggests that in most cases, use of improved varieties and/or quality seed is associated with modest yield increases.  In the sample of 395 trials reviewed, positive yield changes accompanied the use of improved variety or quality seed, on average, in 10 out of 12 crops, with rice and cassava as the two exceptions.

EPAR Technical Report #302
Publication Date: 04/29/2015
Type: Literature Review
Abstract

The review consists of a summary of the emergence of agribusiness clusters, SEZs and incubators since 1965 (with a focus on smallholder agriculture-based economies in Latin America, Africa, and Asia), followed by a series of brief case studies of example programs with particular relevance for guiding proposed clusters/incubators in the countries of Ethiopia, Tanzania, Nigeria and the Eastern Indian states of Uttar Pradesh, Bihar, and Odisha. Summary conclusions draw upon published reports and primary analysis of case studies to highlight apparent determinants of success and failure in agribusiness investment clusters and incubators, including characteristics of the business environment (markets, policies) and characteristics of the organizational structure (clusters, accelerators) associated with positive smallholder outcomes. 

EPAR Technical Report #298
Publication Date: 03/23/2015
Type: Literature Review
Abstract

Cassava production is prone to many constraints throughout the production cycle, including biotic, abiotic, and management constraints. This brief reviews the literature on the production impacts of two key cassava stressors: cassava bacterial blight (CBB) and postharvest physiological deterioration (PPD). We summarize available estimates of the frequency and magnitude of these constraints relative to other drivers of cassava production losses that affect smallholder farmers in Sub-Saharan Africa (SSA), review the control strategies proposed in the literature, report on the views of several experts in the field, and identify research gaps where relatively little appears to be known about CBB or PPD yield impacts or best practices for CBB or PPD management. 

EPAR Technical Report #295
Publication Date: 02/22/2015
Type: Literature Review
Abstract

This report reviews the literature on textural attributes of Root, Tuber, and Banana (RTB) crops with a focus on studies relevant for crop research and development in Sub-Saharan Africa. The texture of cooked root and tuber crops is often cited as a primary determinant of consumer acceptability of new varieties, including those produced through traditional breeding and through genetic engineering. Evidence from texture-related consumer preferences studies for the RTB crops tropical yam, sweetpotato, banana/plantain, cassava, and potato, as well as the results of physicochemical and genetic studies detailing the current scientific understanding of drivers of textural traits, is reviewed and synthesized.

EPAR Technical Report #223
Publication Date: 12/10/2012
Type: Literature Review
Abstract

Cassava is a tuber crop originating in South America and grown in tropical and subtropical areas throughout the world. Cassava use varies significantly by region. In Africa, cassava is primarily grown for food. In Asia, production is typically for industrial purposes, including ethanol, while in Latin America and the Caribbean it is commonly used in animal feed. Both roots and leaves are consumed, though most information on production focuses on roots. There are bitter and sweet varieties; bitter cassava has a high cyanide content and must be processed prior to consumption, while sweet varieties can be eaten directly. This report presents information about current production, constraints, and future potential of cassava. We discuss cassava’s importance in Africa, current worldwide production, projections for supply and demand, production constraints, and current policies affecting cassava production and trade. We include global information but focus on Africa, particularly Nigeria, Ghana, Uganda, and Tanzania.

EPAR Technical Report #199
Publication Date: 07/27/2012
Type: Literature Review
Abstract

Over the past 20 years, global wheat production and consumption have increased significantly. Production has increased 28%, or about 1.3% annually, and consumption has increased about 24%, or 1.1% annually. A small number of countries consistently account for over 90% of the export market, but the import market is more diversified and involves many more countries. Wheat is primarily used for food, seed, and industry; only 20% of wheat production is used for animal feed. This brief provides a global overview of the wheat value chain, but with specific attention to three focus countries: Ethiopia, India (specifically the Bihar region), and Bangladesh. While these three countries currently have a limited impact in the global wheat market, projections of wheat production and demand suggest that over the next 20 years demand in Bangladesh and Ethiopia will increasingly exceed supply, while India will become a net importer by 2030.

EPAR Technical Report #114
Publication Date: 12/14/2010
Type: Literature Review
Abstract

As part of the Crops & Climate Change series, this brief is presented in three parts: 1) An evaluation of the importance of wheat in SSA, based on production, net exports, and caloric need, 2) A novel analysis of historical and projected climate conditions in wheat-growing regions, followed by a summary of the agronomic and physiological vulnerability of wheat crops, 3) A summary of current resources dedicated to wheat, based on research and development investments and National Adaptation Programmes of Action. Overall, this analysis indicates that the importance of wheat as an imported product remains high throughout SSA, though food crop production and dependence is concentrated in a relatively small area. Wheat-growing regions throughout SSA are likely to face yield decreases as a result of predicted rises in temperatures and possible changes in precipitation. Resources intended to aid adaptation to climate change flow primarily from public sector research and development efforts, though country-level adaptation strategies have not prioritized wheat.

EPAR Technical Report #115
Publication Date: 12/14/2010
Type: Literature Review
Abstract

As part of the Crops & Climate Change series, this brief is presented in three parts: 1) An evaluation of the importance of Sorghum and Millet in SSA, based on production, net exports, and caloric need, 2) A novel analysis of historical and projected climate conditions in Sorghum and Millet growing regions, followed by a summary of the agronomic and physiological vulnerability of Sorghum and Millet crops, 3) A summary of current resources dedicated to sorghum and millet, based on research and development investments and National Adaptation Programmes of Action. Our analysis indicates that sorghum and millets may become increasingly important in those areas of SSA predicted to become hotter and subject to more variable precipitation as a result of climate change. Although sorghum and millet are currently grown on marginal agricultural lands and consumed for subsistence by poorer population segments, climate change could render these drought- and heat-tolerant crops the most viable future cereal production option in some areas where other cereals are currently grown. Fewer international development resources are currently devoted to sorghum and millet than are devoted to other cereal grains, and current resource allocation may not reflect the increased reliance on these grains necessitated by projected climactic changes.