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EPAR Technical Report #346
Assessing Pharma’s Constraints, Opportunities, and Investment Options in Global Health R&D: An Analysis of SEC 10-K Filings
Publication Date: 04/23/2018
Type: Literature Review
Abstract

The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.

Executive Summary, Full Report
EPAR Technical Report #218
China Agricultural Machinery
Publication Date: 01/13/2013
Type: Literature Review
Abstract

This desk study reports on the small-scale machinery sector in China and a selection of SSA countries: Ethiopia, Tanzania, Nigeria, Burkina Faso, and Uganda. The report is organized into three sections. Section 1 discusses the current state of small-scale agricultural machinery in SSA for crop and livestock production in each of the SSA countries identified. It also seeks to identify major areas of need in terms of agricultural mechanization and major constraints to agricultural machinery adoption, dissemination and maintenance. Section 2 focuses on the agricultural machinery sector in China and Chinese Africa relationships in agricultural development. It also identifies the major government players in the Chinese agricultural machinery sector. Section 3 is a “directory” of small-scale agricultural machinery manufactured in China with potential relevance for SSA smallholder farmers. We divide machines by function (e.g. threshing) although many Chinese machines are multi-function and can serve multiple purposes. We also note applicable crops, if listed by the manufacturers, and technical specifications as available.

Literature Review
EPAR Research Brief #167
LSMS-ISA Tanzania Section B: Median Farmer Profile
Publication Date: 10/07/2011
Type: Data Analysis
Abstract

This is "Section B" of a report that presents estimates and summary statistics from the 2008/2009 wave of the Tanzania National Panel Survey (TZNPS), part of the Living Standards Measurement Study – Integrated Surveys on Agriculture (LSMS-ISA). We present our analyses of household characteristics by gender and by administrative zone, considering landholding size, number of crops grown, yields, livestock, input use, and food consumption.

Full Report
EPAR Technical Report #160
LSMS-ISA Tanzania Section C: Household Characteristics and Education
Publication Date: 09/30/2011
Type: Data Analysis
Abstract

This is "Section C" of a report that presents estimates and summary statistics from the 2008/2009 wave of the Tanzania National Panel Survey (TZNPS), part of the Living Standards Measurement Study – Integrated Surveys on Agriculture (LSMS-ISA). We present our analyses of the basic characteristics of household heads and other household members, as well as our analyses of education for adults, children, and household heads by gender and zone.

Full Report
EPAR Research Brief #143
Asset-Based Community Development Applications
Publication Date: 04/18/2011
Type: Literature Review
Abstract

Asset-Based Community Development (ABCD) is a development framework which focuses on the capacities, skills and social resources of people and their communities, rather than initially focusing on the needs, deficiencies, constraints and problems of a community.1 This document contains three sections. The first section summarizes several papers which either (1) apply ABCD or similar asset-focused development frameworks in a rural/agricultural context and to development in Sub-Saharan Africa, or (2) provide general guidance on the implementation of ABCD approaches to development. The second section provides more detail on how Oxfam and the Coady International Institute have applied ABCD in Ethiopian communities.
Finally, in order to provide an example of how ABCD might be applied to a Foundation project, the third section briefly notes how an ABCD strategy might differ from the Foundation’s proposed constraints-based Bihar strategy.

Literature Review
EPAR Technical Report #130
Waste Treatment and Reuse
Publication Date: 01/29/2011
Type: Literature Review
Abstract

The purpose of this literature review is to provide qualitative and quantitative examples of technologies, constraints and incentives for efficient waste treatment and reuse in Sub-Saharan Africa and Southeast Asia.  We present relevant case studies and expert observations and experiences on the nutrient content in urine and feces, contaminants frequently found in untreated sludge and wastewater, waste treatment technologies that may be relevant for low-income countries, risks associated with waste reuse, benefits to resource recovery in agriculture. We further discuss reasons for waste treatment failures, including urbanization, observations on challenges with market-driven reuse in less developed countries, and examples of net-positive energy facilities in Europe and the United States. Much of the evidence presented in the literature relates to wastewater treatment processes or the sludge produced from wastewater treatment as opposed to untreated fecal sludge.  However, examples of risks, failures, and opportunities for raw sludge treatment and reuse are discussed when available.  In some cases, empirical evidence or case studies were not available for developing countries and alternatives are presented.  Overall we found the empirical evidence on waste treatment and reuse in developing countries is quite thin. 

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