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The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.
In Tanzania, agriculture represents approximately 50 percent of GDP, 80 percent of rural employment, and over 50 percent of the foreign exchange earnings. Yet poor soil fertility and resulting low productivity contribute to low economic growth and widespread poverty. Chemical fertilizer has the potential to contribute to crop yield increases. Yet high prices and weaknesses in the fertilizer market keep fertilizer use low. This literature review examines the history of government interventions that have intended to increase access to fertilizers, and reviews current policies, market structure, and challenges that contribute to the present conditions. We find that despite numerous strategies over the last fifty years, from heavy government involvement to liberalization, major weaknesses in Tanzania’s fertilizer market prevent efficient use of fertilizer. High transportation costs, low knowledge level of farmers and agrodealers, unavailability of improved seed, and limited access to credit all contribute to the market’s problems. The government’s current framework, the Tanzania Agriculture Input Partnership (TAIP), acknowledges this interconnectedness by targeting multiple components of the market. This model could help Tanzania tailor solutions relevant to specific road, soil, and market conditions of different areas of the country, contributing to enhanced food security and economic growth.
This literature review provides information on the dynamics of the maize market and maize prices in Zambia. We address four key topics: average production costs and breakeven prices for maize farmers in Zambia, main drivers of volatility of maize production volumes, key factors driving the differences between Zambian and global maize prices, and policies that may have contributed to increased farmer productivity.